A healthy Humphrey and Hamilton, and maybe we have a different outcome. With that said, Macdonald is absolutely horrid at having his defense hold a lead. He plays scared. He got a sack, or big loss a few times yesterday on 1st and 2nd down. He followed that up with a soft zone, giving up 10+ yards underneath, and allowing a huge completion to easily be made. Enough of the free releases and "sticks" zone BS. Play like you've been playing. Let your press-man corners hit somebody at the line, and disrupt their routes. We have Dean Pees all over again. No lead is safe with the jackass in the booth.
I wholeheartedly believe that you can't scheme for bad secondary play, and this game shows you why. When Humphrey was out for a couple series Lawrence walked all over us, and Hamilton almost certainly would have been a difference maker today with how well he's played. I also think that MacDonald has been hiding Peters as best he can, because Peters has been a liability all season. I don't think he's 100% yet. He can't hide Peters when Humphrey is also missing time, and one of your starting safeties is also out.