Gonna be tough to run against Cleveland. They totally stifled Miami's running game (and Miami has a pretty respectable o-line, generally speaking). Cleveland's inside linebackers are incredible athletes and I think it will be tough for Rice and Pierce to break big gains.
That said, Cleveland also blitzed the crap out of Miami, and Tannehill easily picked them apart when they did. He hit his hot read repeatedly as Cleveland brought 5 and 6 blitzers. Joe should be alright if they blitz us that often.
Also, I haven't watched a ton of Weeden film, but I do know that two of the three picks last week were not really his fault. Both passes in question hit the receiver in the hands at chest-level and bounced straight up into a defender's waiting arms. The third pick, though, was totally on Weeden. A badly thrown deep ball into double coverage. Our secondary should be alright. Weeden relentlessly stares down his target and has trouble going to his second and third read. This will be like a day off compared to Manning. Only advantage Weeden has is his arm. He's got a cannon and can hit his receiver even if the guy is pretty tightly covered.
Ravens should win, but it won't be as clean as people want it to be. I'd imagine the pass-run ratio will be pretty tilted again, which may not make fans happy.