Not the Cardinals game? If you live where I think you once said, that might be easier than the 49ers game, especially if your wife isn't too keen on you being gone for Christmas.
Phoenix and San Fran are almost the same distance, San Fran being marginally closer. The flip side being that it won't cost me about $70 for a hamburger in Phoenix.
This is also assuming I drive. But Phoenix is a possibility. We could turn it into a camping trip with the family.
I feel like the 49ers and Chargers games are more compelling for me though in terms of matchups, because the Chargers have Herbert, and the 49ers seem to always be a good matchup with the Ravens.