Duke Johnson being out this game is big blow for the Texans, as that type of back tends to be a difficult match up at times, they can design off the edge runs or get him in space to make a few dents in the armor. David Johnson likes to dance and hit the hole, not quite as deliberate as Bell was in Pittsburgh, but its noticeable. He does not like to go between the tackles and is always looking to bounce it out off tackle. It means maintain lane discipline and Johnson does not really pose a threat. Wink knows how to prepare for Johnson and his preferred style with stifling numbers against him his entire career. Also note, Johnson has a paltry YPA & YAC against AFC North clubs known for rugged run defense.
Cooks is 80% and running on a spare tire. His quad is torn in the muscle and he just can't push off or hit another gear without pain and stiffness. I don't see him as a factor in the passing game, as he is mainly isolated as a deep threat at this point of his career.
Fuller is a good match up for Humphrey and Peters, but at 35% target share rate this might be a one trick pony offense that Watson better move off from if he has any shot at beating playoff caliber teams and the air yards rate means that he is the main target in the five and seven step drop backs. It's not like Hopkins taking that share rate and then you have to factor with Fuller and Stills. When you take away the king, the pulpier can't step up to be king and change the landscape; it's a glaring hole that will take the Texans offense weeks, or months to fully understand how to gameplan properly...time that would have been best served with a full offseason and pre-season games...which they didn't get and will hurt them early in the season.
I would go heavy blitz and force the David Johnson to pick up the blitz, tire him out as early as possible because they don't have a viable option to back into Duke Johnson reps. It also clogs the lanes and forces Watson to throw off his back foot, which he typically does a handful of times a game.